・Clinical research for the treatments of cerebrovascular diseases.
・Clinical research of Cerebral blood flow and metabolism at the post neurosurgical states.
・Clinical investigation of flow dynamics of DVA associated with cavernous malformation.
・Clinical research of the plaque diagnosis using NIRS-IVUS technology for carotid stenosis.
・Clinical investigation of the correlation between preoperative BOT and intraoperative MEP monitoring during CEA for carotid stenosis.
・Clinical investigation of the correlation between preoperative LSFG and intraoperative MEP monitoring during CEA for carotid stenosis.
・Clinical investigation of the factors related to the paradoxical augmentation of MEP wave during temporally occlusion of MCA.
・Clinical investigation of the pudendal stimulation method for the more reliable MEP monitoring.
・Clinical investigation of the strategy for the intracranial arterial dissections.
・Clinical research of the efficacy of the ICG angiography to the surgical procedures for the intracranial arterial dissections.
・Clinical research of the efficacy of the ICG angiography to the preservation of cerebral veins during the surgical procedures for ruptured cerebral aneurysms.
・Clinical research for the efficacy of the facial nerve monitoring for skull base surgery.
・Clinical investigation of the PEEM monitoring induced by FEF stimulation.
・Clinical research for the less invasive spinal neurosurgical techniques.
・Clinical research for the stable MEP monitoring during spinal surgery.
・Clinical research for the 3D-fusion imaging assisted neurological surgery.
・Clinical research of the operative approach of basilar artery aneurysm based on 3D-fusion images.
・Clinical research of the cerebral venous structures for the cerebral aneurysm surgery based on 3D-fusion images.
・Clinical research for the Neuro-Endoscopy assisted neurosurgical surgery.
・Clinical research for the Hypothermia therapy for the severe brain injury of infancy.
・Observational Study for Symptomatic Epilepsy of the post stroke patients.
・Clinical investigation of the Identification method of the Epileptic foci using high frequency vibrational spectrum EEG and Intraoperative cortical EEG under general anesthesia with Sevoflurane inhalation.
Clinical Multi-institutional Joint Research
・Genetic Research for pediatric intracranial malignant tumors (medulloblastoma,
ependymoma).
・Phase 2 stage clinical trial of tailor-made Therapy, using MGMT-methylation
identification, for high-aged GBM patients.
・CSPS.com study (Cilostazol Stroke Prevention Study/ Combination)
・COSMO-JAPAN study (Cognitive dysfunction Survey of Moyamoya)
・SUAVe-PEGASUS trial (Small Unruptured Aneurysm Verification Prevention Effect
against Growth of cerebral Aneurysm Study Using Statin).
・Phase 2 stage clinical trial of Chemo-Radiation Therapy for the initial intracranial
germinomas.
・Phase 2/3 stage double blind randomized clinical trial of the efficacy and safety of
HLCM051(Multistem) for the patients suffered from cerebral infarction.
・Phase 2 stage clinical trial of the efficacy of Clazosentan for
vasospasm due to the ruptured cerebral aneurysms.
・Clinical Research of the endocrinological and neuro-clinical effects
by doses of Octreotide-LAR to the acromegaly patients.
・BIOMARK trial (Phase 2 study of bevacizumab beyond progression
disease for glioblastoma treated with key therapeutics.)
・RADICAL trial (Phase II study of implantation of carmustine wafers,
followed by radiation therapy and concomitant temozolomide and
bevacizumab for newly diagnosed glioblastoma.)
Basic Medical Study in Our Lab
・Basic research of Cerebro-Vascular disturbance: MCA occlusion model, dural AVF
model etc.
・Basic research of Cerebro-Venous disturbance: 2 vein occlusion model.
・Electro-physiological Investigation of Ischemic Post-Conditioning.
・Basic research of the Influences of the Hypo-oxygen Environments to the Migration
and Differentiations of Endogenous neural stem cells.
・Investigations of the Immuno-Chemotherapy for GBM with Immuno-deficient mouse.
・Investigations of the mechanisms of the Ischemic tolerance phenomenon via Mito-K-ATP channel.